Status quo

Unfortunately, good news did not come our way today. Another BFN. I did not feel positive about this cycle from the beginning. Here is a recap:

Retrieval - 4 days past estimate - donor was responding to meds; however, growth of follicles was slow and there was a concern about hyperstimulation. 13 eggs retrieved (Each of my own retrieval cycles produced many more eggs than this but who's counting?). Of the 13, 5 eggs were immature, 3 did not fertilize, 1 embryo had cell division problems, which resulted in 4 embryos on day 3.

Transfer - all along the plan was to transfer on Day 5, but because we had less than 6 embryos the clinic asked us to come in on Day 3. The Dr. mentioned that we could come back on Day 5, but I was an emotional wreck and just wanted to continue on with the transfer. We transferred 3 embryos (one 10 cell and 2 eiqht cells - all beginning to compact with little fragmentation). We let the remaining embryo continue in culture to see if it would make it to blast.

Cryo news - The remaining embryo did not make it to blast. This confirmed in my mind that we would most probably not have a BFP.

I am pretty frustrated at this point - I know that I have not had good results on my own (i.e. BFP), but each of my own retrieval cycles resulted in at least one blast and I have had 4 FET's from my cycles. I assumed that we would have had much better results from a donor.

The donor that we chose had one previous cycle before ours and it resulted in a chemical - I specifically asked about her previous cycle before we chose her and was informed that there were sperm issues in that cycle (not sure if they had to perform rescue ICSI or what) but was assured that we did not have this same issue.

I guess what I am trying to say is that I am pissed off. What the fxxx? This was supposed to be the answer.

TM mentioned that maybe we have a different issue other than egg quality, but I am at a loss to know what else could be out there. My FSH was a little over 6, my HSG was normal, both of our karotyping was normal, I respond well to meds, no issues with retrievals or transfers, lots of eggs, lots of blasts, 70-80% thaw rate for the blasts, (though please note - my embryos have been graded right about a 2 with some fragmentation - but each time, "They look good" per our Doc). The issue of egg quality came up during our first retrieval cycle as we had to go in on a day 3, but we did end up having blasts from that cycle also. What am I missing here?

We could have done PGD (and I wish that we had now), but since we had had so many failures we were encouraged to go right on to donor egg. The Doc seemed convinced that we have an egg issue.

We will probably schedule our cycle review right away, neither of us is very patient and I want to get a plan in place. We talked about adoption again today, but neither of us is ready to give up yet.